Electrochemically driven direct C–H difluoroethylation of (hetero)arenes under metal/catalyst-free conditions
An efficient electrochemical method for the regioselective difluoroethylation of various (hetero)arenes was smoothly accomplished. Without metal catalysts and external oxidants involved, this method leads to the easy accessibility of valuable CF<sub>2</sub>Me-substituted architectures. Notably, this electrochemical protocol successfully enabled the other valuable fluoroalkylation of heteroarenes. The controlled experiments indicated that a radical mechanism was involved in this transformation. The mild reaction conditions, excellent functional group compatibility, and good efficiency and selectivity render this method a promising strategy for late-stage modification of bioactive complex molecules.
Authors
- Yunfei Tian (ORCID: https://orcid.org/0000-0002-8198-2346)
- Zejiang Li (ORCID: https://orcid.org/0000-0001-9579-9895)
- Weijun Fu (ORCID: https://orcid.org/0000-0002-0377-6432)
- Yuanfeng Liang
- Jiahui Zhang (ORCID: https://orcid.org/0009-0008-4087-8674)
- Jiajia Wang (ORCID: https://orcid.org/0000-0001-9633-7246)
- Jiayi Zhang (ORCID: https://orcid.org/0000-0003-2434-4329)
- Zhihui Gao
- Zheng LuPing
Institutions
- Luoyang Normal University (CN)
- Ministry of Education (TW)
- Hebei University (CN)
- Beihang University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc01983d
- Citations
- 6
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 4.74
Funders
- National Natural Science Foundation of China
- Hebei University
- Key Scientific Research Project of Colleges and Universities in Henan Province
- Integrative and Collaborative Education and Research