Counties with Low Employment and Education Status Are Associated with Higher Age-Adjusted Cancer Mortality

<b>Background:</b> This study aims to evaluate the potential relationship between county-level social determinants of health (SDOH)-specifically education and job status-and cancer mortality. <b>Methods</b>: We utilized Social Determinants of Health (SDOH) data from the Agency for Healthcare Quality (AHRQ) 2015 county database for a cross-sectional study investigating the primary independent variables-low education and low employment status-and the outcome of cancer mortality. <b>Results</b>: Out of 3134 counties, 906 exhibited poor employment levels, while 467 showed low educational attainment. The age-adjusted cancer death rate for non-low-education counties was 172.90 [157.00, 188.40], but for low-education counties it was 186.20 [161.72, 209.33], <i>p</i> < 0.001. Conversely, this was 169.15 [154.00, 183.50], compared to 189.80 [171.90, 207.10], <i>p</i> < 0.001, for counties with low employment. The adjusted analysis indicated that counties with low education levels were correlated with elevated age-adjusted cancer mortality (7.68, 95% CI: 5.06-10.31), and similarly, counties with low employment rates were linked to increased age-adjusted cancer mortality (4.69, 95% CI: 2.58-6.79). <b>Conclusions</b>: Our findings indicate that counties characterized by low educational attainment and poor employment levels are associated with elevated age-adjusted cancer death rates.