A Convenient Synthesis Of Heterocyclic Oxazinyl Derivatives Of -4,5-Dihydro-1H-Pyrazole-5-Carbonyl-Naphthalen-2(1H)-One, -2-Mercaptopyrimidin-4-Yl-Naphthalen-2(1H)-One, 2-Hydroxypyrimidin-4-Yl-Naphthalen-2(1H)-One And Their Antimicrobial Activity

A versatile and convenient synthesis of new cyclize derivatives derived from chalone. First synthesized the 3-acetyl-2H-chromenone-2 by the condensation of salicylaldehyde, ethyl acetoacetate and N-(unsubstituted/substituted-aryl)- di 3, 4-hydro- 2H-benzo [e,1,3] oxazine-carb-6-aldehyde formed by using p-hydroxy aldehyde and substituted aromatic amine to form (E)-3-(3-(N-(unsubstituted/substituted-aryl)-di-3, 4-hydro- 2H-benzo [e,1,3] oxazinyl-7)acryloyl)-3-acetylcoumarin which were than cyclized using hydrazine hydrates, thiourea and urea to furnish the pyrazole-carbonyl, hydroxy-pyrimidinyl and mercapto-pyrimidinyl. We characterized these derivatives with the help of IR, 1HNMR, and mass spectral studies, The antimicrobial activity was assessed in vitro by serial dilution method.33