The MAP kinase negative regulator DUSP2 (dual specificity phosphatase 2) is controlled by oncogenic microRNA cluster miR-17-92, miR-106a-363 and miR-106b-25
The results of this study indicate that microRNA-mediated regulation of DUSP2 in hematologic and solid cancers appears to be a plausible mechanism that contributes to the dysregulation of MAP kinase signaling pathways in cancer by impairing negative feedback regulation. The data provide a solid foundation for future studies to investigate the consequences of regulation of DUSP function in cancer in more depth.
Authors
- Ole Morten Seternes (ORCID: https://orcid.org/0000-0001-8537-3612)
- Ingolf Cascorbi (ORCID: https://orcid.org/0000-0002-2182-9534)
- Henrike Bruckmueller
- Victoria Tenhaken
Institutions
- Centre for Arctic Gas Hydrate, Environment and Climate (NO)
- University Hospital Schleswig-Holstein (DE)
- UiT The Arctic University of Norway (NO)
- University of Lübeck (DE)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1186/s12885-025-14434-z
- Citations
- 2
- Primary Topic
- Protein Tyrosine Phosphatases
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Helse Nord RHF