Comparison of the Effect of Platelet-rich Plasma and Injectable Platelet-rich Fibrin on the Rate of Orthodontic Tooth Movement: A Prospective Split-mouth Randomized Clinical Study

Introduction The extended duration of traditional orthodontic treatment remains a significant patient concern. This study compared platelet-rich plasma (PRP) and injectable platelet-rich fibrin (i-PRF) for accelerating orthodontic tooth movement (OTM) and assessing associated pain. Methods A total of 11 patients were studied using a split-mouth design, with randomized allocation of PRP to one quadrant and i-PRF to the contralateral quadrant. Interventions were administered at 21-day intervals. Canine retraction rates were measured using dental casts, while pain perception was quantified via visual analog scale (VAS) during a 1-week follow-up period. Results The i-PRF group demonstrated significantly faster OTM (2.13 ± 0.31 mm/month) compared to PRP (1.61 ± 0.28 mm/month; P = .0002), representing a 32.3% increase in movement rate. Pain levels were low but statistically higher with i-PRF (VAS 2.26 ± 0.98) versus PRP (VAS 1.9 ± 1.0; P = .0001), though both remained within clinically acceptable ranges. Conclusion i-PRF is more effective in accelerating OTM than PRP, with only marginally greater transient discomfort. These findings support i-PRF as a clinically viable biological adjunct for reducing orthodontic treatment duration.