The phosphatase PPM1F, a negative regulator of integrin activity, is essential for embryonic development and controls tumor cell invasion
These results highlight the non-redundant role of this enzyme in integrin and PAK regulation and identify PPM1F as a promising target to limit tumor metastasis.
Authors
- Erik Sontowski (ORCID: https://orcid.org/0000-0001-9287-0721)
- Christoph Paone
- Timo Baade
- Christof R. Hauck (ORCID: https://orcid.org/0000-0002-1005-2141)
- Nina I. Dierdorf
- Marleen Herbinger
- Sarah Baumgärtner
- Tanja Grimm
Institutions
- University of Konstanz (DE)
Publication Details
- Journal
- BMC Biology
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1186/s12915-025-02254-3
- Citations
- 2
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 3.24
Funders
- Deutsche Forschungsgemeinschaft
- Universität Konstanz