EZH2 expression in colorectal carcinoma: an evaluation of clinicopathological and prognostic value
EZH2 is highly expressed across the normal-adenoma-carcinoma sequence and, in our cohort, was not linked to overall survival or to most clinicopathologic parameters in CRC. The lower expression observed in a subset of MSI-H tumors warrants further investigation; present evidence remains insufficient to establish EZH2 as an independent prognostic biomarker.
Authors
- Mecdi Gürhan Balcı (ORCID: https://orcid.org/0000-0003-3713-3344)
- Gizem Issın (ORCID: https://orcid.org/0000-0002-3688-2768)
- Diren Vuslat Çağatay (ORCID: https://orcid.org/0000-0002-8391-1891)
- Fatih Demir (ORCID: https://orcid.org/0000-0002-8181-0739)
Institutions
- Gümüşhane University (TR)
- Erzincan Binali Yıldırım University (TR)
- Düzce Üniversitesi (TR)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1007/s12672-025-02990-6
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Erzincan Üniversitesi