Spherical k-means clustering in the cisplatin resistome of oral cancer

Resistance to cisplatin (CDDP) in oral cancer presents a significant challenge, driven by mechanisms such as enhanced DNA repair, increased drug efflux, and altered cell cycle regulation. BRCA1 and BRCA2 are tumour suppressor genes. They play a crucial role in DNA repair and cell cycle control, helping to prevent cancer development. Mutations in these genes increase the risk of developing several cancers. These key genes, BRCA1 and BRCA2, are crucial in repairing cisplatin-induced DNA damage. Resistance involves off-target mechanisms like ERBB2, DYRK1B, TMEM205, and RAB8A overexpression.