Quantitative spectral computed tomography detects different patterns of airway wall thickening and contrast enhancement in infective lung disease: a feasibility study
Question Is spectral CT airway contrast enhancement a feasible quantitative method to detect airway inflammation or neovascularisation? Findings Spectral CT shows significant differences in segmental wall thickness and airway contrast enhancement between COVID-19 and non-COVID-19 pneumonia, and lung-healthy controls. Clinical relevance Spectral CT can be used to assess inflammatory airway diseases such as cystic fibrosis, COPD, asthma and bronchiectasis.
Authors
- Arndt Lukas Bodenberger
- Wolfram Stiller (ORCID: https://orcid.org/0000-0001-9951-6020)
- Mark Oliver Wielpütz (ORCID: https://orcid.org/0000-0001-6962-037X)
- Thuy Duong (ORCID: https://orcid.org/0000-0003-2561-3404)
- Oliver Weinheimer (ORCID: https://orcid.org/0000-0002-9507-076X)
- Philip Konietzke (ORCID: https://orcid.org/0000-0001-8580-6721)
- Hans‐Ulrich Kauczor (ORCID: https://orcid.org/0000-0002-6730-9462)
- Tim Frederik Weber (ORCID: https://orcid.org/0000-0001-5911-123X)
- Willi L. Wagner (ORCID: https://orcid.org/0000-0002-2748-5429)
- Claus Peter Heußel (ORCID: https://orcid.org/0000-0001-5809-5733)
- John A. Thoma
Institutions
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- German Center for Lung Research (DE)
Publication Details
- Journal
- European Radiology
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1007/s00330-025-11752-5
- Primary Topic
- Advanced X-ray and CT Imaging
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bundesministerium für Bildung und Forschung
- Deutsches Zentrum für Lungenforschung