Class A Orphans in GtoPdb v.2025.2
Table 1 lists a number of putative GPCRs identified by NC-IUPHAR [197], for which preliminary evidence for an endogenous ligand has been published, or for which there exists a potential link to a disease, or disorder. These GPCRs have recently been reviewed in detail [153]. The GPCRs in Table 1 are all Class A, rhodopsin-like GPCRs. Class A orphan GPCRs not listed in Table 1 are putative GPCRs with as-yet unidentified endogenous ligands.Table 1: Class A orphan GPCRs with putative endogenous ligands GPR3GPR4GPR6GPR12GPR15GPR17GPR20 GPR22GPR26GPR31GPR34GPR35GPR37GPR39 GPR50GPR63GPR65GPR68GPR75GPR84GPR87 GPR88GPR132GPR149GPR161GPR183LGR4LGR5 LGR6MAS1MRGPRDMRGPRX1MRGPRX2P2RY10TAAR2 In addition the orphan receptors GPR18, GPR55 and GPR119 which are reported to respond to endogenous agents analogous to the endogenous cannabinoid ligands have been grouped together (GPR18, GPR55 and GPR119).
Authors
- Adam J Pawson (ORCID: https://orcid.org/0000-0003-2280-845X)
- Tom I. Bonner
- Nicholas D. Holliday (ORCID: https://orcid.org/0000-0002-2900-828X)
- Khuraijam Dhanachandra Singh (ORCID: https://orcid.org/0000-0003-0506-6896)
- Satoru Eguchi (ORCID: https://orcid.org/0000-0002-8407-7501)
- Sadashiva S. Karnik (ORCID: https://orcid.org/0000-0003-0746-2753)
- Richard R. Neubig (ORCID: https://orcid.org/0000-0003-0501-0008)
- Richard V. Benya
- Eliot R. Spindel
- Andrew J. Irving (ORCID: https://orcid.org/0000-0003-1417-4792)
- Laura Storjohann
- Kalyan Tirupula
- Jean‐Philippe Pin (ORCID: https://orcid.org/0000-0002-1423-345X)
- Helen E. Benson
- Amy E. Monaghan (ORCID: https://orcid.org/0000-0003-0302-6989)
- Evi Kostenis (ORCID: https://orcid.org/0000-0001-8284-5514)
- Anthony P. Davenport (ORCID: https://orcid.org/0000-0002-2096-3117)
- Walter G. Thomas (ORCID: https://orcid.org/0000-0003-0685-2952)
- Wen Chiy Liew
- Leigh A. Stoddart (ORCID: https://orcid.org/0000-0002-4469-0600)
- Joanna L Sharman (ORCID: https://orcid.org/0000-0002-5275-6446)
- Chido Mpamhanga
- Michael Spedding (ORCID: https://orcid.org/0000-0002-1248-8221)
- Patrick Vanderheyden
- S P H Alexander (ORCID: https://orcid.org/0000-0003-4417-497X)
- Anthony J. Harmar (ORCID: https://orcid.org/0000-0002-3838-9264)
- Robert T. Jensen (ORCID: https://orcid.org/0000-0002-0095-4600)
- Jim Battey
Institutions
- University College Dublin (IE)
- LifeArc (GB)
- National Institutes of Health (US)
- Vrije Universiteit Brussel (BE)
- University of Bonn (DE)
- University of Nottingham (GB)
- The University of Queensland (AU)
- Oregon Health & Science University (US)
- Université de Montpellier (FR)
- University of Utah (US)
- University of Cambridge (GB)
- Temple College (US)
- Cleveland Clinic Lerner College of Medicine (US)
- University of Illinois Chicago (US)
- Clinical Research Solutions (US)
- University of Glasgow (GB)
- Temple University (US)
- Michigan State University (US)
- University of Edinburgh (GB)
Publication Details
- Journal
- IUPHAR/BPS Guide to Pharmacology CITE
- Published
- 2025-06-18
- DOI
- https://doi.org/10.2218/gtopdb/f16/2025.2
- Primary Topic
- Receptor Mechanisms and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00