ARID1A deficiency promotes malignant proliferation of hepatocellular carcinoma by activating HDAC7/ENO1 signaling pathway
This study provides novel insights into the regulatory interplay between chromatin remodeling and acetylation modification, 2 pivotal epigenetic processes influencing tumorigenesis. It also suggests that pharmacological inhibition of HDAC7 offers a promising therapeutic strategy for treating HCC with ARID1A mutations.
Authors
- Wenjiao Chang
- Xiaoling Ma (ORCID: https://orcid.org/0000-0002-2732-8669)
- Xinghua Han (ORCID: https://orcid.org/0000-0002-0632-6955)
- Pengsheng Ding
- Gang Wu (ORCID: https://orcid.org/0000-0001-8941-2500)
- Shanshan Zhang (ORCID: https://orcid.org/0000-0001-6458-8585)
- Gan Liu (ORCID: https://orcid.org/0000-0002-6165-3799)
- Lan Shi (ORCID: https://orcid.org/0000-0002-2405-2548)
- Yuanyuan Dai (ORCID: https://orcid.org/0000-0001-6487-7803)
Institutions
- University of Science and Technology of China (CN)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1097/hc9.0000000000000738
- Citations
- 4
- Primary Topic
- Chromatin Remodeling and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.22