Rbpj deletion in hepatic progenitor cells attenuates endothelial responses and fibrosis in DDC-fed mice
Our findings reveal Rbpj-dependent expression of reactive cholangiocyte markers in HPCs and demonstrate that Rbpj deletion in HPCs attenuates not only endothelial responses but also liver injury, fibrosis, and VCAM1 expression in cholangiocytes, highlighting the crucial role of HPCs in pathogenic progression.
Authors
- Stacey S. Huppert (ORCID: https://orcid.org/0000-0003-3977-8728)
- Soona Shin (ORCID: https://orcid.org/0000-0001-5696-9505)
- Aditi Paranjpe (ORCID: https://orcid.org/0000-0002-3566-3993)
- Sanghoon Lee (ORCID: https://orcid.org/0000-0002-1265-3821)
- Weiwei Li (ORCID: https://orcid.org/0000-0002-5390-2417)
- Ping Zhou (ORCID: https://orcid.org/0000-0002-5792-6790)
- Lu Ren (ORCID: https://orcid.org/0009-0000-7967-1314)
- Andrew Potter
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1097/hc9.0000000000000745
- Citations
- 2
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 2.64