Ceramide kinase suppresses ferroptosis and protects against alcohol-associated liver disease through the p38 MAPK–HSPB1 pathway
Our findings indicated that enhancing CERK expression or activity may represent a novel therapeutic strategy for mitigating alcohol-induced liver injury. This approach could offer a promising avenue for treating ALD and its associated ferroptotic damage.
Authors
- Lan Bai (ORCID: https://orcid.org/0000-0002-8859-1540)
- Yeben Qian (ORCID: https://orcid.org/0000-0002-3145-3745)
- Ye Tao (ORCID: https://orcid.org/0000-0001-5862-9520)
- Hongni Wang (ORCID: https://orcid.org/0000-0002-2491-3838)
- Hua Wang
- Yongqiang Chen (ORCID: https://orcid.org/0000-0003-3395-8023)
- Yao Peng (ORCID: https://orcid.org/0000-0001-8992-8814)
- Xiang Liu (ORCID: https://orcid.org/0009-0008-9958-745X)
- Guisheng Qi
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Anhui Medical University (CN)
- Gannan Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1097/hc9.0000000000000731
- Citations
- 2
- Primary Topic
- Alcohol Consumption and Health Effects
- Type
- article
- Field-Weighted Citation Impact
- 2.94