Sex-related differences in cognition after severe murine traumatic brain injury: A Morris water maze study evaluating learning and memory
Severe TBI worsens cued and spatial learning and impairs weight loss recovery in male but not female mice. Female, but not male, mice sustain memory impairment after identical severe TBI. While the mechanism(s) that underpin these observations remain unclear, sex-related neurocognitive outcome differences question the universal applicability of trial-based evidence for clinical care.
Authors
- Priyanka Bele
- Michael James Coons (ORCID: https://orcid.org/0000-0001-9093-0815)
- Patricia Martinez‐Quinones (ORCID: https://orcid.org/0000-0001-9704-0268)
- José L. Pascual (ORCID: https://orcid.org/0000-0002-1613-7912)
- Anastasia P Georges (ORCID: https://orcid.org/0000-0001-6340-8327)
- Lewis J. Kaplan (ORCID: https://orcid.org/0000-0002-1514-1274)
- Gary Alan Bass (ORCID: https://orcid.org/0000-0002-1918-9443)
- Matthew C. Culkin
- D. Howard Smith
- Christina L. Jacovides (ORCID: https://orcid.org/0000-0003-0985-6860)
- David F. Meaney (ORCID: https://orcid.org/0000-0002-0954-4122)
- Patricia Santos Carlin
- Alexandra Kauffman
Institutions
- MACOM (United States) (US)
Publication Details
- Journal
- The Journal of Trauma: Injury, Infection, and Critical Care
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1097/ta.0000000000004668
- Primary Topic
- Traumatic Brain Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00