HBV promotes epithelial-mesenchymal transition in HCC and liver fibrosis through JNK-mediated autophagy
In conclusion, HBV induces autophagy through JNK, thus triggering downstream EMT and fibrogenesis signaling pathways. These findings suggest that JNKs could be potential targets for the treatment of HBV-related liver diseases.
Authors
- Raymond T. Chung (ORCID: https://orcid.org/0000-0001-7587-718X)
- Qiuju Sheng (ORCID: https://orcid.org/0000-0001-6683-9309)
- Jian Hong (ORCID: https://orcid.org/0000-0002-7209-1349)
- Min Xu (ORCID: https://orcid.org/0000-0002-6936-7543)
- Wenting Li (ORCID: https://orcid.org/0000-0001-7734-4838)
- Wen‐Yu Lin (ORCID: https://orcid.org/0000-0002-4979-2921)
- Dong Chen
- Shadi Salloum
- Olivia Mezzetti (ORCID: https://orcid.org/0009-0000-6414-1249)
Institutions
- Harvard University (US)
- Sun Yat-sen University (CN)
- Jinan University (CN)
- Anhui Medical University (CN)
- Massachusetts General Hospital (US)
- First Affiliated Hospital of Anhui Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1097/hc9.0000000000000730
- Citations
- 2
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 2.71