Development of a prognostic immune cell-based model for ovarian cancer using multiplex immunofluorescence
This study highlights the prognostic value of immune cell spatial distribution in ovarian cancer. The ICRPI model, integrating immune cell markers and spatial analysis, provides a novel framework for predicting patient outcomes. Further validation in prospective studies is warranted to confirm the clinical utility of this model.
Authors
- Bo Jiang (ORCID: https://orcid.org/0000-0001-8341-1750)
- Sifu Yang (ORCID: https://orcid.org/0000-0001-6364-5488)
- Yupeng Hong
- Sai Li (ORCID: https://orcid.org/0000-0002-9353-0355)
- Yang Liu (ORCID: https://orcid.org/0000-0001-8405-2817)
- Hongying Zhou (ORCID: https://orcid.org/0000-0002-5229-9564)
Institutions
- Women's Hospital, School of Medicine, Zhejiang University (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1186/s12967-025-06745-3
- Citations
- 3
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- National Natural Science Foundation of China
- Science and Technology Department of Zhejiang Province
- Medical Science and Technology Project of Zhejiang Province
- Natural Science Foundation of Zhejiang Province