GLIPR2 regulates EndoMT and cardiac fibrosis after AMI via PDGFRL/AKT/mTOR signaling pathway
GLIPR2 promotes cardiac fibrosis repair by regulating EndoMT through the PDGFRL/AKT/mTOR signaling pathway. Its inhibition represents a potential therapeutic strategy to mitigate cardiac fibrosis and improve ventricular function following AMI.
Authors
- Yu-tao Xie (ORCID: https://orcid.org/0000-0003-1634-2059)
- Zijie Huang (ORCID: https://orcid.org/0000-0002-8911-9889)
- Li Wan (ORCID: https://orcid.org/0000-0002-0839-3748)
- Shuangmei Li
- Yajie Guo (ORCID: https://orcid.org/0000-0001-5473-207X)
- Huibao Long
- Xuxiang Chen (ORCID: https://orcid.org/0000-0003-4084-0218)
- Cuicui Meng
- Tong Wang (ORCID: https://orcid.org/0000-0003-4644-4179)
- Hao Wu (ORCID: https://orcid.org/0000-0001-8010-7729)
- Shujun Yang (ORCID: https://orcid.org/0009-0009-3963-264X)
- Shihan Yuan
Institutions
- Sun Yat-sen University (CN)
- Eighth Affiliated Hospital of Sun Yat-sen University
Publication Details
- Journal
- Life Sciences
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1016/j.lfs.2025.123816
- Citations
- 4
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 5.55