The effects of retinal disease on intrinsic protein disorder and liquid–liquid-phase separation
This study revealed significant variations in protein intrinsic disorder and liquid-LLPS across healthy and diseased retinal proteomes. The highest levels of disorder in the HPA proteome suggest a proteomic flexibility that is critical for normal retinal function. In contrast, the AMD and glaucoma proteomes, with their lower disorder and LLPS propensity, may lack this adaptability, potentially contributing to disease progression. These insights underscore the importance of protein dynamics in retinal disorders and point towards targeted therapies that could manipulate these properties to improve or maintain retinal health.
Authors
- Jose S. Pulido
- Michael Antonietti (ORCID: https://orcid.org/0000-0001-5526-1396)
- Mak B. Djulbegovic (ORCID: https://orcid.org/0000-0002-4149-7450)
- Carol L. Karp (ORCID: https://orcid.org/0000-0002-6452-7181)
- Vladimir Nikolaevich Uversky (ORCID: https://orcid.org/0000-0002-4037-5857)
- David J. Taylor Gonzalez (ORCID: https://orcid.org/0009-0001-2089-6153)
- Colin K. Kim
- Nedym Hadzijahic
Institutions
- Massachusetts Eye and Ear Infirmary (US)
- Harvard University (US)
- University of Miami (US)
- Thomas Jefferson University (US)
- University of Tennessee Health Science Center (US)
- University of South Florida (US)
- USF Health Byrd Alzheimer's Institute (US)
- Wills Eye Hospital (US)
Publication Details
- Journal
- Journal of Proteins and Proteomics
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1007/s42485-025-00188-6
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 0.00