Neurological Immune-Related Adverse Events in Patients Treated with Anti-PD-1 agent, Pembrolizumab: A Case Series
Neurological immune-related adverse effects (n-irAEs) are rare, and their identification poses a challenge due to their complexity and the presence of underlying autoimmune and paraneoplastic disorders. The expected prognosis for n-irAEs is unclear, presenting a range of complete recovery rates and differing mortality outcomes. The increased frequency of ICI usage increases the probability of an immune response, necessitating healthcare professionals to identify new symptoms in immunotherapy patients. Side effects differ from conventional chemotherapy and necessitate different therapeutic approaches.
Authors
- Bahram Haghi-Ashtiani (ORCID: https://orcid.org/0000-0002-3373-740X)
- Tara Khoeini (ORCID: https://orcid.org/0000-0002-6351-6499)
- Fateme Rahattalab
- Sepehr Khosravi (ORCID: https://orcid.org/0000-0002-2764-8128)
Institutions
- Iran University of Medical Sciences (IR)
Publication Details
- Journal
- Case Reports in Neurology
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1159/000547004
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00