Neurological Immune-Related Adverse Events in Patients Treated with Anti-PD-1 agent, Pembrolizumab: A Case Series

Neurological immune-related adverse effects (n-irAEs) are rare, and their identification poses a challenge due to their complexity and the presence of underlying autoimmune and paraneoplastic disorders. The expected prognosis for n-irAEs is unclear, presenting a range of complete recovery rates and differing mortality outcomes. The increased frequency of ICI usage increases the probability of an immune response, necessitating healthcare professionals to identify new symptoms in immunotherapy patients. Side effects differ from conventional chemotherapy and necessitate different therapeutic approaches.

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Publication Details

Journal
Case Reports in Neurology
Published
2025-06-19
DOI
https://doi.org/10.1159/000547004
Primary Topic
Cancer Immunotherapy and Biomarkers
Type
article
Field-Weighted Citation Impact
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article

Neurological Immune-Related Adverse Events in Patients Treated with Anti-PD-1 agent, Pembrolizumab: A Case Series

Bahram Haghi-Ashtiani, Tara Khoeini, Fateme Rahattalab, Sepehr Khosravi
Case Reports in Neurology
Cancer Immunotherapy and Biomarkers
article

Neurological Immune-Related Adverse Events in Patients Treated with Anti-PD-1 agent, Pembrolizumab: A Case Series

Bahram Haghi-Ashtiani, Tara Khoeini, Fateme Rahattalab, Sepehr Khosravi
article en

Abstract

Neurological immune-related adverse effects (n-irAEs) are rare, and their identification poses a challenge due to their complexity and the presence of underlying autoimmune and paraneoplastic disorders. The expected prognosis for n-irAEs is unclear, presenting a range of complete recovery rates and differing mortality outcomes. The increased frequency of ICI usage increases the probability of an immune response, necessitating healthcare professionals to identify new symptoms in immunotherapy patients. Side effects differ from conventional chemotherapy and necessitate different therapeutic approaches.

Case Reports in NeurologyVol. 17(1)
Iran University of Medical Sciences (IR)
Good health and well-being
Openalex Percentile: Top 78%
Cancer Immunotherapy and Biomarkers
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