Structural Connectivity of the Basal Ganglia from Patient-Individual Tractography Is Key for Understanding the Effects of Deep Brain Stimulation in Parkinson’s Disease
Patient-individual tractography reveals that, in PD, most of the cortical fibres traversing the VTA are connected to the SMA. In addition, clinical efficacy is related to the proportion of DBS-affected fibres connecting the STN with nodes of both the hyperdirect (cortex-STN) and the indirect pathways (STN-basal ganglia). As such, patient-specific tractography, in particular in the basal ganglia, could be used in a clinical context as a tool to guide therapy.
Authors
- Ricardo Loução (ORCID: https://orcid.org/0000-0002-0310-0352)
- Veerle E. R. M. Visser-Vandewalle (ORCID: https://orcid.org/0000-0002-5274-7929)
- Brendan Santyr (ORCID: https://orcid.org/0000-0003-1782-4527)
- Martin Köcher (ORCID: https://orcid.org/0000-0002-5674-9227)
- Haidar S. Dafsari (ORCID: https://orcid.org/0000-0001-8849-4233)
- Pablo Andrade (ORCID: https://orcid.org/0000-0002-2596-7301)
- Tolga Çukur (ORCID: https://orcid.org/0000-0002-2296-851X)
- Alessandro Bongioanni (ORCID: https://orcid.org/0000-0002-4996-6098)
- David E.J. Linden (ORCID: https://orcid.org/0000-0002-5638-9292)
- Robert Jech (ORCID: https://orcid.org/0000-0002-9732-8947)
- Josef Mana (ORCID: https://orcid.org/0000-0002-7817-3978)
- Halim Ibrahim Baqapuri (ORCID: https://orcid.org/0000-0003-4360-3621)
- Andrés M. Lozano (ORCID: https://orcid.org/0000-0001-8257-3694)
- Jochen Wirths
- Béchir Jarraya (ORCID: https://orcid.org/0000-0003-0878-763X)
- Michael T. Barbe (ORCID: https://orcid.org/0000-0003-1149-8054)
- Gregor A. Brandt (ORCID: https://orcid.org/0000-0002-9984-2069)
- Michael Luehrs
- Jan Niklas Petry-Schmelzer
Institutions
- Inserm (FR)
- Bilkent University (TR)
- University of Cologne (DE)
- University of Toronto (CA)
- Université de Versailles Saint-Quentin-en-Yvelines (FR)
- Charles University (CZ)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Université Paris-Saclay (FR)
- Toronto Western Hospital (CA)
- Maastricht University Medical Centre (NL)
- Maastricht University (NL)
- CEA Paris-Saclay (FR)
- Brain Innovation (Netherlands) (NL)
- Cognitive Neuroimaging Lab (FR)
- University Hospital Cologne (DE)
- Hôpital Foch (FR)
Publication Details
- Journal
- Stereotactic and Functional Neurosurgery
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1159/000546716
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- EU Joint Programme – Neurodegenerative Disease Research
- Agence Nationale de la Recherche
- Ministerstvo Školství, Mládeže a Tělovýchovy
- ZonMw
- Bundesministerium für Bildung und Forschung
- Türkiye Bilimsel ve Teknolojik Araştırma Kurumu
- Canadian Institutes of Health Research