Synergistic effects of PAR2 and TrkA exacerbate visceral hypersensitivity induced by chronic pancreatitis in rats
Mast cells contribute to chronic pancreatitis pain through enrichment and degranulation. The interaction of PAR2 and TrkA exacerbates chronic pancreatitis pain, which may be a potential strategy for the treatment of chronic pancreatitis -induced visceral pain.
Authors
- Zhijie Lu (ORCID: https://orcid.org/0000-0002-0561-0591)
- Haibo Qiu (ORCID: https://orcid.org/0000-0001-8589-4717)
- Qianbo Chen (ORCID: https://orcid.org/0009-0002-0541-1522)
- Kunming Tao (ORCID: https://orcid.org/0000-0002-1683-3424)
- Xiaodan Wu (ORCID: https://orcid.org/0000-0001-6289-1644)
- Kai Wei (ORCID: https://orcid.org/0000-0001-7068-6114)
- Zhiyun Liu (ORCID: https://orcid.org/0009-0001-1896-0937)
- Jiao Zhu (ORCID: https://orcid.org/0000-0002-8152-5268)
Institutions
- Fujian Medical University (CN)
- Second Military Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Shanghai Chest Hospital (CN)
- Shanghai Ninth People's Hospital (CN)
- Minhang District Central Hospital (CN)
- Fujian Provincial Hospital (CN)
Publication Details
- Journal
- IBRO Neuroscience Reports
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1016/j.ibneur.2025.06.012
- Citations
- 2
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China
- Second Military Medical University
- Program of Shanghai Academic Research Leader