MPC-based postural control: Mimicking CNS strategies for head–neck stabilization under eyes closed conditions

A plausible explanation about the acquisition and realization of beliefs by the central nervous system (CNS) when issuing control actions to counteract external perturbations, is to employ mechanisms aiming to minimize sensory conflict and muscle effort while maintaining biomechanical stability. However, existing head–neck postural control models fail to explicitly integrate this plausible CNS objective within their stabilization mechanisms. This study proposes a novel Model Predictive Control (MPC)-based framework to replicate CNS postural stabilization by incorporating the minimization of sensory conflict as a primary control objective through the MPC cost function. The MPC is integrated in a simplified biomechanical head–neck structure, using a prediction model and sensory feedback to optimize control actions over a finite time horizon within biomechanical constraints. Two human experiments measuring head motion with unpredictable seat and trunk perturbations were used to evaluate and validate different configurations of sensory feedback pathways. During anterior–posterior translational trunk perturbations, the results illustrated that the configuration with vestibular feedback improved head position prediction while muscle effort and partial somatosensory feedback alone, achieved superior results in head pitch prediction. Meanwhile, muscle effort and partial somatosensory feedback were sufficient to stabilize the head during trunk rotational (pitch) perturbations. Finally, a multi-scenario optimization demonstrated that a single set of MPC weights could generalize stabilization across both perturbation types. The results demonstrate the effectiveness of MPC in replicating CNS-inspired postural adjustments, indicating that controlling a simplified biomechanical head–neck model provides a computationally efficient and accurate alternative to complex multi-segment approaches. • First MPC-based control to replicate head–neck postural stabilization. • Modeled CNS plausible objectives of minimizing sensory conflict using the MPC cost function. • Validated model with experimental data for two perturbation types under eyes-closed tests. • Outperformed complex multi-segment models in efficiency without compromising stability performance. • Unified MPC weights stabilized the model across anterior–posterior and pitch perturbations.