The fibrin-derived peptide FX06 protects human pulmonary endothelial cells against the COVID-19-triggered cytokine storm
Overall, FX06 shows promising potential in normalizing ECs and reducing vascular leakage to protect the endothelium against the proinflammatory effect of COVID-19-triggered cytokines.
Authors
- Laura V. Doyle (ORCID: https://orcid.org/0000-0003-1241-7017)
- Kai Zacharowski (ORCID: https://orcid.org/0000-0002-0212-9110)
- Vadim Zhernovkov (ORCID: https://orcid.org/0000-0001-8903-1142)
- Z G Wang
- S.Sai Manish Rao
- Walter Kölch (ORCID: https://orcid.org/0000-0001-5777-5016)
- Günther Eißner
- Kevin A. Wu (ORCID: https://orcid.org/0000-0001-8296-1152)
- Alfonso Blanco (ORCID: https://orcid.org/0000-0003-0439-0838)
- Petra Wülfroth
- Dimitri Scholz (ORCID: https://orcid.org/0000-0002-3695-2041)
- Jeremy C. Simpson (ORCID: https://orcid.org/0000-0002-7956-7805)
- Margaritha M. Mysior (ORCID: https://orcid.org/0000-0001-5096-2361)
- Kieran J. Wynne (ORCID: https://orcid.org/0000-0001-5759-5285)
- Simeng Li (ORCID: https://orcid.org/0000-0002-9708-0400)
- Д. А. Лебедев (ORCID: https://orcid.org/0000-0003-1808-1331)
Institutions
- University College Dublin (IE)
- Goethe University Frankfurt (DE)
- University Hospital Frankfurt (DE)
- Institute for Pharmaeconomic Research (AT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-19
- DOI
- https://doi.org/10.3389/fimmu.2025.1591860
- Citations
- 1
- Primary Topic
- Biomarkers in Disease Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.80