An optimized peritonitis-induced ACLF model that reproduces the full spectrum of extrahepatic organ failures in mice
The CCl4+CLP model reproduces the full spectra of extrahepatic organ impairments present in patients with ACLF and represents an optimized murine model to experimentally explore the pathophysiology of this disease as well as new therapeutic approaches.
Authors
- Joan Clària (ORCID: https://orcid.org/0000-0003-4333-7749)
- Albert Salvatella
- Jonel Trebicka (ORCID: https://orcid.org/0000-0002-7028-3881)
- Roger Flores‐Costa (ORCID: https://orcid.org/0000-0002-8711-2552)
- Jordi Bosch (ORCID: https://orcid.org/0000-0001-9263-3371)
- Pierre‐Emmanuel Rautou (ORCID: https://orcid.org/0000-0001-9567-1859)
- Cristina López‐Vicario (ORCID: https://orcid.org/0000-0002-6609-8501)
- Frank Erhard Uschner (ORCID: https://orcid.org/0000-0002-3760-2887)
- Bryan J. Contreras
- Alba Díaz (ORCID: https://orcid.org/0000-0002-0456-7085)
- David Gómez-Cabrero (ORCID: https://orcid.org/0000-0003-4186-3788)
- Marta Duran‐Güell (ORCID: https://orcid.org/0000-0002-3265-395X)
- Estefanía Huergo (ORCID: https://orcid.org/0000-0001-5063-099X)
- Berta Romero-Grimaldo (ORCID: https://orcid.org/0000-0002-9249-5615)
- Sabine Klein (ORCID: https://orcid.org/0000-0001-6691-2895)
- María Belén Sánchez-Rodríguez
Institutions
- Inserm (FR)
- Universidad Pública de Navarra (UPNA) (ES)
- University of Münster (DE)
- Hôpital Beaujon (FR)
- European Foundation for the Study of Chronic Liver Failure (ES)
- Hospital Clínic de Barcelona (ES)
- Navarrabiomed (ES)
- Grifols (Spain) (ES)
- Centre de Recherche sur l'Inflammation (FR)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- King Abdullah University of Science and Technology (SA)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1097/hc9.0000000000000744
- Citations
- 1
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 1.32