An optimized peritonitis-induced ACLF model that reproduces the full spectrum of extrahepatic organ failures in mice

The CCl4+CLP model reproduces the full spectra of extrahepatic organ impairments present in patients with ACLF and represents an optimized murine model to experimentally explore the pathophysiology of this disease as well as new therapeutic approaches.

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Publication Details

Journal
Hepatology Communications
Published
2025-06-19
DOI
https://doi.org/10.1097/hc9.0000000000000744
Citations
1
Primary Topic
Liver Disease and Transplantation
Type
article
Field-Weighted Citation Impact
1.32
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article

An optimized peritonitis-induced ACLF model that reproduces the full spectrum of extrahepatic organ failures in mice

Joan Clària, Albert Salvatella, Jonel Trebicka, Roger Flores‐Costa et al.
1 citations
Hepatology Communications
Liver Disease and Transplantation
1.32
article

An optimized peritonitis-induced ACLF model that reproduces the full spectrum of extrahepatic organ failures in mice

Joan Clària, Albert Salvatella, Jonel Trebicka, Roger Flores‐Costa, Jordi Bosch, Pierre‐Emmanuel Rautou, Cristina López‐Vicario, Frank Erhard Uschner, Bryan J. Contreras, Alba Díaz, David Gómez-Cabrero, Marta Duran‐Güell, Estefanía Huergo, Berta Romero-Grimaldo, Sabine Klein, María Belén Sánchez-Rodríguez
article en
1 citations

Abstract

The CCl4+CLP model reproduces the full spectra of extrahepatic organ impairments present in patients with ACLF and represents an optimized murine model to experimentally explore the pathophysiology of this disease as well as new therapeutic approaches.

Hepatology CommunicationsVol. 9(7)
Inserm (FR), Universidad Pública de Navarra (UPNA) (ES), University of Münster (DE), Hôpital Beaujon (FR), European Foundation for the Study of Chronic Liver Failure (ES), Hospital Clínic de Barcelona (ES), Navarrabiomed (ES), Grifols (Spain) (ES), Centre de Recherche sur l'Inflammation (FR), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES), Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES), King Abdullah University of Science and Technology (SA), Universitat de Barcelona (ES)
Good health and well-being
Openalex Percentile: Top 19%
Liver Disease and Transplantation
1.32
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