Characterization of a thermostable uricase derived from Thermoactinospora rubra YIM 77501T and its heat-resistant mechanism
These results demonstrate TrUox as a robust uricase exhibiting dual advantages of catalytic efficiency and enhanced thermostability, positioning it as a promising biocatalyst for industrial-scale production and therapeutic development. Our preliminary study into its thermostable mechanism provides a theoretical foundation for future production and research.
Authors
- Wei Hu (ORCID: https://orcid.org/0000-0002-6678-9468)
- Li Yang
- Linhua Li (ORCID: https://orcid.org/0000-0001-7878-1570)
- Nancy Jin
- Lei Tang (ORCID: https://orcid.org/0000-0001-5465-610X)
- Maite Ortúzar (ORCID: https://orcid.org/0000-0003-4985-9978)
- Yi-Rui Yin
- Peng Sang
- Wenjun Li (ORCID: https://orcid.org/0000-0003-4017-2520)
- Yanwen Wang (ORCID: https://orcid.org/0000-0003-0640-8552)
- Xin Yan (ORCID: https://orcid.org/0000-0001-8658-7444)
- Zheng-Feng Yang
Institutions
- Sun Yat-sen University (CN)
- Kunming Medical University (CN)
- Plateau State University (NG)
- Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
- Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai) (CN)
- Dali University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-06-19
- DOI
- https://doi.org/10.3389/fmicb.2025.1615845
- Citations
- 2
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 2.86