Mass Spectrometry-Based Untargeted Metabolomics Identifies Distinct Metabolic Signatures in Infertility: A Comparative Analysis of PCOS, POR, and NOR
This study reveals phenotype-specific metabolic signatures in PCOS and POR, identifying taurocholate, mycalemide, and N,N-dimethylglycine as potential follicular biomarkers. These findings contribute to a deeper understanding of the metabolic basis of infertility and highlight the potential of follicular fluid metabolomics for precision medicine in reproductive health.
Authors
- Şahabettin Selek (ORCID: https://orcid.org/0000-0003-1235-3957)
- Ebru GÜNER (ORCID: https://orcid.org/0009-0005-6420-1391)
- Fatmanur Köktaşoğlu (ORCID: https://orcid.org/0000-0002-3201-5923)
- Yıldız Atamer (ORCID: https://orcid.org/0000-0002-0934-4278)
- Metin Demirel (ORCID: https://orcid.org/0000-0003-4810-6771)
- Mehtap Alim (ORCID: https://orcid.org/0000-0003-0818-7714)
- Atakan Aydın (ORCID: https://orcid.org/0000-0002-3568-3513)
- Nil Atakul (ORCID: https://orcid.org/0000-0003-3874-8797)
- Sanem Naz Kafali
Institutions
- Üsküdar University (TR)
- Bezmiâlem Vakıf Üniversitesi (TR)
- Istanbul Eye Hospital (TR)
- Beykent University (TR)
Publication Details
- Journal
- Reproductive Sciences
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1007/s43032-025-01908-5
- Citations
- 2
- Primary Topic
- Ovarian function and disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.40
Funders
- Bezmialem Vakıf Üniversitesi