Poor Diagnostic Performance of the Melanin-Binding Tracer [18 F]MEL050 in Human Melanoma Indicates Biological Heterogeneity
We propose caution in the use of melanin-targeted agents for melanoma diagnosis and therapy until their utility as prognostic or predictive imaging biomarkers, and the biological implications of loss of melanin deposition during melanoma progression, are better understood.
Authors
- Peter D. Roselt (ORCID: https://orcid.org/0000-0003-2310-5377)
- Catherine Mitchell (ORCID: https://orcid.org/0000-0001-5596-9511)
- Wayne Noonan
- Damien Kee (ORCID: https://orcid.org/0000-0002-4685-1666)
- Marnie Downes (ORCID: https://orcid.org/0000-0002-0677-2517)
- William K. Murray
- Grant A. McArthur (ORCID: https://orcid.org/0000-0001-8908-6071)
- Mark Shackleton (ORCID: https://orcid.org/0000-0002-7673-4655)
- Rodney J. Hicks (ORCID: https://orcid.org/0000-0002-0758-0824)
- Ivan Greguric (ORCID: https://orcid.org/0000-0002-2291-9881)
- Thomas Bourdier (ORCID: https://orcid.org/0000-0003-0640-9985)
- Andrew Katsifis (ORCID: https://orcid.org/0000-0002-0856-9985)
- Robert E. Ware
Institutions
- The University of Sydney (AU)
- Translational Research Institute (AU)
- Australian Nuclear Science and Technology Organisation (AU)
- The University of Melbourne (AU)
- Royal Prince Alfred Hospital (AU)
- Peter MacCallum Cancer Centre (AU)
- Murdoch Children's Research Institute (AU)
- Alfred Health (AU)
- Monash University (AU)
- St Vincents Institute of Medical Research (AU)
- Blackburn College (US)
Publication Details
- Journal
- Molecular Imaging and Biology
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1007/s11307-025-02025-0
- Primary Topic
- Cutaneous Melanoma Detection and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Australian Government
- University of Melbourne