Extracellular Vesicle-Derived MicroRNAs as a Biomarker for Therapeutic Response in Multiple Sclerosis
This study underscores the potential of specific EV characteristics and microRNA content as early biomarkers for treatment response in patients with MS. The downregulation of specific microRNAs emerges as a promising indicator of favorable clinical outcomes, thereby suggesting their utility in early therapeutic decision making. Notably, our findings regarding miR-186-5p as a biomarker for brain atrophy represent a novel contribution to the field. Overall, early EV levels and microRNA content analysis at 3 months after treatment initiation seem to be promising as regards anticipating irreversible neurologic damage, thereby offering a valuable tool for optimizing MS treatment management.
Authors
- María Gutiérrez‐Fernández (ORCID: https://orcid.org/0000-0002-6615-4729)
- Inmaculada Puertas (ORCID: https://orcid.org/0000-0002-9567-1274)
- Elisa Alonso‐López (ORCID: https://orcid.org/0000-0001-7299-2916)
- Rodrigo Barderas (ORCID: https://orcid.org/0000-0003-3539-7469)
- Beatriz Chamorro
- Gabriel Torres-Iglesias
- Rubén Ayala-Suárez (ORCID: https://orcid.org/0000-0002-1271-6466)
- Mireya Fernández-Fournier (ORCID: https://orcid.org/0000-0002-4885-0181)
- Laura Otero‐Ortega (ORCID: https://orcid.org/0000-0001-8765-6341)
- Fernando Laso-García (ORCID: https://orcid.org/0000-0002-5481-0514)
- MariPaz López-Molina (ORCID: https://orcid.org/0000-0002-9171-2606)
- Exuperio Díez-Tejedor
- Ana Montero-Calle
- Beatriz Egido
Institutions
- Instituto de Salud Carlos III (ES)
- Hospital La Paz Institute for Health Research (ES)
- Unidad Funcional de Investigación de Enfermedades Crónicas (ES)
- Universidad Autónoma de Madrid (ES)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1212/nxi.0000000000200420
- Citations
- 6
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 4.84