Knockdown of Telethonin Reduces Contractions and Provokes Aberrant Ca<sup>2+</sup>-waves in Human iPS Cell-induced Cardiomyocytes
We found that <i>TCAP</i>-KD in human iPS cell-induced CMs impairs contraction, induces triggered activities, and abnormal Ca<sup>2+</sup>-waves, which is consistent with the phenotypes of DCM.
Authors
- Takashi Miida (ORCID: https://orcid.org/0000-0002-4294-8030)
- Isik Turker (ORCID: https://orcid.org/0000-0003-3216-3499)
- Yoko Tabe (ORCID: https://orcid.org/0000-0002-3734-0346)
- Tetsuya Handoh
- Yuna Horiuchi
- Tomohiko Ai (ORCID: https://orcid.org/0000-0003-0376-0227)
- Hideki Yamamoto (ORCID: https://orcid.org/0000-0003-4919-3483)
- Atsushi Hori (ORCID: https://orcid.org/0009-0000-1961-7404)
- Haruka Inaba
Institutions
- University of Washington (US)
- Juntendo University (JP)
- Juntendo University Urayasu Hospital (JP)
Publication Details
- Journal
- Juntendo Medical Journal
- Published
- 2025-01-01
- DOI
- https://doi.org/10.14789/ejmj.jmj24-0025-oa
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.00