Crotonylation driving Streptococcus pneumoniae adaption and virulence
Our findings shed light on the molecular mechanisms underlying PLY hemolytic activity regulated by Kcr, revealing its importance in bacterial survival and virulence. Overall, this research provides valuable insights into the important biological roles of Kcr in S.pn and offers potential theoretical foundations for developing new antibacterial drugs.
Authors
- Xuesong Sun (ORCID: https://orcid.org/0009-0009-6302-6498)
- Yun-Dan Zheng
- Zuye Fang
- Nan Li (ORCID: https://orcid.org/0000-0002-7121-7579)
- Yan Liu (ORCID: https://orcid.org/0000-0002-2566-6867)
- Qing‐Yu He (ORCID: https://orcid.org/0000-0003-0503-9492)
- Yun-Peng Yang
- Xinyu Ye (ORCID: https://orcid.org/0000-0002-8654-699X)
- Jiayi Xu (ORCID: https://orcid.org/0000-0002-5558-9372)
- Jiayi Wu (ORCID: https://orcid.org/0000-0002-3809-0692)
- Jianpeng Zhuang
- Z. Xue (ORCID: https://orcid.org/0009-0009-6401-5504)
Institutions
- Jinan University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1016/j.jare.2025.06.045
- Primary Topic
- Pneumonia and Respiratory Infections
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province