Genetic mechanisms, brain structures, and peripheral biomarkers mediate the relationship between physical frailty and neuropsychiatric disorders
This study provides comprehensive evidence linking physical frailty to brain dysfunction, suggesting that early frailty intervention is a potential strategy for preventing brain dysfunction and neuropsychiatric disorder.
Authors
- Lingzhi Ma (ORCID: https://orcid.org/0000-0001-8963-0030)
- Jianfeng Feng (ORCID: https://orcid.org/0000-0001-5987-2258)
- Pei‐Yang Gao (ORCID: https://orcid.org/0009-0002-7559-1215)
- Wei Cheng (ORCID: https://orcid.org/0000-0003-1118-1743)
- Yi‐Xuan Qiang
- Yiming Huang (ORCID: https://orcid.org/0000-0002-6888-9622)
- Yi‐Jun Ge
- Xiao‐Yu He
- Lan Tan (ORCID: https://orcid.org/0000-0002-8759-7588)
- Dandan Zhang (ORCID: https://orcid.org/0000-0001-5305-9856)
- Zhibo Wang (ORCID: https://orcid.org/0000-0002-5804-3279)
- Wei Zhang (ORCID: https://orcid.org/0000-0003-0548-6348)
- Jia Emil You (ORCID: https://orcid.org/0009-0001-2931-0905)
- Yaru Zhang (ORCID: https://orcid.org/0000-0002-6167-7248)
- Bing Zhao (ORCID: https://orcid.org/0000-0002-5758-4559)
- Haihong Yu (ORCID: https://orcid.org/0000-0001-7604-2387)
- Jin‐Tai Yu (ORCID: https://orcid.org/0000-0002-2532-383X)
- Ya‐Nan Ou
- Hao‐Chen Chi
- Yan Fu (ORCID: https://orcid.org/0000-0001-8300-4573)
Institutions
- Qingdao University (CN)
- Capital Medical University (CN)
- Fudan University (CN)
- Shanghai Institute for Science of Science (CN)
- Affiliated Hospital of Qingdao University (CN)
- Qingdao Municipal Hospital (CN)
- Huashan Hospital (CN)
- Shanghai Center for Brain Science and Brain-Inspired Technology (CN)
- State Key Laboratory of Medical Neurobiology
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1016/j.jare.2025.06.046
- Primary Topic
- Frailty in Older Adults
- Type
- article
- Field-Weighted Citation Impact
- 0.00