Response

We appreciate the response to our study that examined the effect of acetaminophen on critically ill patients with sepsis who were enrolled in a randomized clinical trial of ibuprofen.1 We agree with the authors on the importance of rigorous data analysis to guide evidence-based care. Our hope for the study was to garner knowledge about the impact of acetaminophen in critically ill patients and lay the groundwork for future investigations. We believe the administration of acetaminophen in critically ill patients warrants further investigation; however, it is important to note that, although the Ibuprofen in Sepsis (ISS) trial recorded acetaminophen use, it was not the study treatment.