Implications of the choice of method to identify major depressive disorder in large research cohorts
Our results demonstrate how the methods used to identify patients with history of MDD can affect sample characteristics and risk factor associations, highlighting the importance of considering phenotype ascertainment in the interpretation of research results.
Authors
- Myrna M. Weissman (ORCID: https://orcid.org/0000-0003-3490-3075)
- Mark Olfson (ORCID: https://orcid.org/0000-0002-3958-5662)
- Lauren Lepow (ORCID: https://orcid.org/0000-0002-1919-6897)
- Braja Gopal Patra (ORCID: https://orcid.org/0000-0003-2997-5314)
- Ardesheer Talati (ORCID: https://orcid.org/0000-0001-5708-1372)
- Jorge A. Sánchez-Ruiz (ORCID: https://orcid.org/0000-0003-4282-7359)
- Brandon J. Coombes (ORCID: https://orcid.org/0000-0003-4322-5923)
- Joanna M. Biernacka (ORCID: https://orcid.org/0000-0001-9350-4440)
- Jyotishman Pathak (ORCID: https://orcid.org/0000-0002-4856-410X)
- Euijung Ryu (ORCID: https://orcid.org/0000-0001-6281-8738)
- J. John Mann (ORCID: https://orcid.org/0000-0002-0265-6586)
- Gregory D. Jenkins (ORCID: https://orcid.org/0000-0001-6408-6227)
- Nicolás A. Núñez (ORCID: https://orcid.org/0000-0003-0404-3529)
- Alexander W. Charney (ORCID: https://orcid.org/0000-0001-8135-6858)
Institutions
- Mayo Clinic (US)
- Cornell University (US)
- University of Utah (US)
- WinnMed (US)
- New York Psychoanalytic Society and Institute (US)
- Mayo Clinic in Florida (US)
- Weill Cornell Medicine (US)
- New York State Psychiatric Institute
- Columbia University (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Journal of Mood and Anxiety Disorders
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1016/j.xjmad.2025.100136
- Primary Topic
- Health Systems, Economic Evaluations, Quality of Life
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Mayo Clinic
- Regeneron Pharmaceuticals
- Center for Individualized Medicine, Mayo Clinic
- National Institute of Mental Health