Scandium‐Catalyzed Highly Selective Deoxygenation of Alcohols by Using Hydrosilanes as Reductants
Herein, we present a straightforward and efficient scandium-based catalytic system that enables highly selective reduction of σ bonds (C─O) in the presence of more reactive π (C═O) or O─H bonds. Employing 5 mol% of Sc(OTf)<sub>3</sub> as the catalyst, a diverse range of aryl and alkyl hydrosilanes proved to be highly effective in reducing secondary and tertiary alcohols to the corresponding alkanes. Furthermore, this protocol was extended to the deoxygenation of ketones and the hydrodehalogenation of alkyl halides.
Authors
- Louis Monsigny (ORCID: https://orcid.org/0000-0001-9325-1316)
- Neethu Thyagarajan (ORCID: https://orcid.org/0000-0002-7883-9418)
- Guillaume Bousrez (ORCID: https://orcid.org/0000-0002-0265-7431)
- Ruqaya Buhaibeh (ORCID: https://orcid.org/0000-0003-1526-2946)
- Emmanuel Nicolas (ORCID: https://orcid.org/0000-0002-0017-5500)
- Thibault Cantat (ORCID: https://orcid.org/0000-0001-5265-8179)
Institutions
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Université Paris-Saclay (FR)
- Institut Rayonnement-Matière de Saclay (FR)
- CEA Paris-Saclay (FR)
Publication Details
- Journal
- Chemistry - A European Journal
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1002/chem.202501596
- Citations
- 2
- Primary Topic
- Organoboron and organosilicon chemistry
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- European Research Council