Pd-catalyzed enantioselective reductive Heck reaction of mono-fluoro, <i>gem</i>-difluoro, and trifluoromethyl tethered-alkenes
Herein, we present an enantioselective, fluorine-retentive Pd-catalyzed reductive Heck cyclization reaction of fluorinated alkenes, enabling the synthesis of all-carbon quaternary 3,3-disubstituted fluoroalkyl-tethered oxindoles. Control experiments and DFT studies have provided insights into the reaction mechanism and stereochemical induction.
Authors
- S. Rajagopala Reddy (ORCID: https://orcid.org/0000-0002-9835-010X)
- M. Ramu Yadav (ORCID: https://orcid.org/0000-0002-9294-0846)
- Hemaang Bhartiya (ORCID: https://orcid.org/0009-0007-4860-0848)
- Swati Jain (ORCID: https://orcid.org/0000-0003-4804-3125)
- Jitendra Singh (ORCID: https://orcid.org/0009-0007-9796-4752)
- Naveen Sihag (ORCID: https://orcid.org/0000-0001-9330-6276)
Institutions
- Indian Institute of Technology Delhi (IN)
- Central University of Rajasthan (IN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc01559f
- Citations
- 1
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.79
Funders
- Council of Scientific and Industrial Research, India
- University Grants Commission
- Indian Institute of Technology Delhi
- Science and Engineering Research Board