Expression pattern and clinical significance of MerTK on circulating NK cells in systemic lupus erythematosus
The expression of MerTK on circulating NK cells was significantly elevated in patients with SLE, particularly in patients with LN, and was correlated with disease activity and autoantibody titres. <i>MERTK</i> expression may be related to regulation of NK cell activation and induced by IFN-I in SLE. Our findings indicate that circulating NK-cell specific expression of MerTK may play a role in the development and progression of SLE.
Authors
- Xiao Han (ORCID: https://orcid.org/0000-0002-5065-4489)
- Ranran Yao (ORCID: https://orcid.org/0000-0002-2733-0048)
- Haojie Xu (ORCID: https://orcid.org/0000-0002-2201-074X)
- Wenwen Pei
- Jianping Guo (ORCID: https://orcid.org/0000-0002-5031-3510)
- Yin Zhu (ORCID: https://orcid.org/0009-0008-0422-6548)
- Ruyu Liang
- Ziye Wang
- Renge Liang
Institutions
- Peking University (CN)
- Peking University People's Hospital (CN)
Publication Details
- Journal
- Lupus Science & Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1136/lupus-2024-001407
- Citations
- 3
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- National Natural Science Foundation of China
- Peking University
- Peking University People's Hospital
- Beijing Municipal Natural Science Foundation
- Beijing Science and Technology Planning Project