Importance of E/e’ and BNP for early detection of late cardiotoxicity in long-term follow-up of childhood hematologic cancer survivors: a retrospective cross-sectional study
In this study, no patient had late symptomatic cardiac complications. However, in those who had survived for a long time since their cancer diagnosis, particularly those with a history of HSCT, there were significant elevations in the E/e' ratio and the BNP level. Continuous follow-up is required to determine whether these abnormalities lead to symptomatic cardiotoxicity and whether they serve as useful markers for the early detection of cardiac complications.
Authors
- Yumiko Inui (ORCID: https://orcid.org/0000-0003-0710-5270)
- Rina Sakai
- Keiko Hatazawa
- T Nose (ORCID: https://orcid.org/0000-0002-8596-6589)
- Shiro Kimbara (ORCID: https://orcid.org/0000-0002-7743-7038)
- Kimikazu Yakushijin (ORCID: https://orcid.org/0000-0003-2511-7857)
- Hiroya Ichikawa (ORCID: https://orcid.org/0009-0001-7659-1172)
- Taiji Koyama (ORCID: https://orcid.org/0000-0002-2893-605X)
- Yoshiaki Nagatani (ORCID: https://orcid.org/0009-0000-6153-6456)
- Keiji Kurata (ORCID: https://orcid.org/0000-0003-1060-9218)
- Hidekazu Tanaka (ORCID: https://orcid.org/0000-0002-1642-7039)
- Yohei Funakoshi (ORCID: https://orcid.org/0000-0001-7793-5013)
- Mitsuhiro Ito (ORCID: https://orcid.org/0000-0001-9505-2441)
- Nobuyuki Yamamoto (ORCID: https://orcid.org/0000-0002-1006-7394)
- Hironobu Minami (ORCID: https://orcid.org/0000-0001-8630-9145)
- Naomi Kiyota
- Sakuya Matsumoto
- Yuri Okazoe-Hirakawa
Institutions
- Kobe University Hospital (JP)
- Kobe University (JP)
Publication Details
- Journal
- Cardio-Oncology
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1186/s40959-025-00354-1
- Primary Topic
- Childhood Cancer Survivors' Quality of Life
- Type
- article
- Field-Weighted Citation Impact
- 0.00