Cold-blooded vertebrates evolved regulatory B cells to participate in inflammatory diseases
These novel findings reveal that fish have evolved Breg with specialized anti-inflammatory functions, providing evolutionary insights into the phylogenetic origin and functional conservation of Breg from fish to mammals.
Authors
- Xu‐Jie Zhang (ORCID: https://orcid.org/0000-0003-2585-534X)
- Xueqing Han
- Carolina Tafalla (ORCID: https://orcid.org/0000-0002-0860-2976)
- Yazhen Hu (ORCID: https://orcid.org/0009-0008-2260-3650)
- Yong‐An Zhang (ORCID: https://orcid.org/0000-0002-9956-3879)
- Tiantian Tian (ORCID: https://orcid.org/0000-0002-6959-3321)
- Xiang-Yang Zhang (ORCID: https://orcid.org/0000-0003-1979-3461)
- Jun Li (ORCID: https://orcid.org/0000-0002-5190-0733)
- Yiru Pan
- Changsong Wu
- Wenjing Dong (ORCID: https://orcid.org/0000-0001-7524-5748)
- Jie Wang (ORCID: https://orcid.org/0009-0001-1008-2236)
Institutions
- Lake Superior State University (US)
- Huazhong Agricultural University (CN)
- National Research Council (LK)
- Fujian Agriculture and Forestry University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1186/s12964-025-02311-y
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- China Postdoctoral Science Foundation
- Huazhong Agricultural University
- Institute of Hydrobiology
- National Key Research and Development Program of China