FCGR2B knockdown alleviates diabetes-induced cognitive dysfunction by altering neuronal excitability
Knock-down FCGR2B within hippocampus of DM mice activated PI3K/AKT signaling pathway via SHC1 in DM mice and alleviated DM-induced cognition impairment. Knock-down FCGR2B alleviated DM-induced cognition impairment by regulating hippocampal neuronal excitability. Thus, this work suggested that FCGR2B may be a potential target for treatment of DM-induced cognitive dysfunction.
Authors
- Yin-Meng Qu
- Ping Wu (ORCID: https://orcid.org/0000-0003-0857-7229)
- Xuan Chen (ORCID: https://orcid.org/0000-0003-2732-0760)
- Yuhao Zhao (ORCID: https://orcid.org/0000-0001-7632-0068)
Institutions
- Jilin University (CN)
- First Hospital of Jilin University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1186/s10020-025-01301-7
- Citations
- 2
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- Natural Science Foundation of Jilin Province
- National Outstanding Youth Science Fund Project of National Natural Science Foundation of China