Transitioning a multiethnic donor pool from serologic D-negative to molecularly RHD-negative at a hospital-based blood donor service
A modular approach for RHD screening is suitable for blood donors when sample pooling is not feasible among multiethnic donor populations. We transitioned donors since 2009 from serologic D-negative to molecularly RHD-negative status at the NIH Clinical Center. Molecular RHD screening of serologic D-negative donors is an effective way to identify individuals harboring DEL alleles that can cause alloimmunization in transfusion recipients.
Authors
- Willy A. Flegel (ORCID: https://orcid.org/0000-0002-1631-7198)
- Nicole F. Dowling
- Kshitij Srivastava (ORCID: https://orcid.org/0000-0002-3658-0815)
- Marina Bueno (ORCID: https://orcid.org/0009-0004-6968-9544)
- Traci D Paige (ORCID: https://orcid.org/0009-0002-8896-6485)
- P. Schmid (ORCID: https://orcid.org/0000-0002-1171-7643)
- Lorraine Caruccio (ORCID: https://orcid.org/0000-0002-0754-097X)
- Santosh Man Shrestha (ORCID: https://orcid.org/0000-0002-2085-7605)
- David Stiles
Institutions
- National Institutes of Health Clinical Center (US)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1186/s12967-025-06716-8
- Citations
- 1
- Primary Topic
- Blood groups and transfusion
- Type
- article
- Field-Weighted Citation Impact
- 1.77
Funders
- U.S. Department of Health and Human Services
- National Institutes of Health
- NIH Clinical Center