Association of epinephrine and outcome in cardiac arrest with refractory shockable rhythm: a population-based, propensity-score matched analysis
In a large population-based registry of patients experiencing refractory ventricular fibrillation, epinephrine use was consistently associated with worse outcome using various methodological approaches. These findings are challenging the systematic use of epinephrine in refractory ventricular fibrillation.The use of potential alternative therapeutic strategies might be evaluated in this population.
Authors
- Éloi Marijon (ORCID: https://orcid.org/0000-0001-7227-3428)
- Lionel Lamhaut (ORCID: https://orcid.org/0000-0003-4160-9456)
- Daniel Jost (ORCID: https://orcid.org/0000-0002-6046-1234)
- Wulfran Bougouin (ORCID: https://orcid.org/0000-0002-1821-7713)
- Florence Dumas (ORCID: https://orcid.org/0000-0002-7651-7909)
- Lucie Fanet
- Alain Cariou (ORCID: https://orcid.org/0000-0003-3258-4672)
- Frankie Beganton (ORCID: https://orcid.org/0000-0001-9734-224X)
- François Javaudin (ORCID: https://orcid.org/0000-0002-7728-2320)
- Xavier Jouven
- Jean‐Philippe Empana
Institutions
- Inserm (FR)
- Université Paris Cité (FR)
- Brigade des Sapeurs Pompiers de Paris (FR)
- Hôpital Cochin (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Européen Georges-Pompidou (FR)
- Paris Cardiovascular Research Center (FR)
- Nantes Université (FR)
Publication Details
- Journal
- Critical Care
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1186/s13054-025-05417-4
- Citations
- 2
- Primary Topic
- Cardiac Arrest and Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 4.51
Funders
- Ramsay Santé