RTA 408 attenuates TBHP-Induced apoptosis in nucleus pulposus cells via Nrf2/ARE and NF-κB signaling pathways: in vitro and in vivo evidence for mitigating rats’ intervertebral disc degeneration

RTA 408 mitigates oxidative stress-induced NPC apoptosis and ECM degradation via dual modulation of Nrf2/ARE activation and NF-κB suppression. Systemic administration of RTA 408 delays IDD progression in vivo, highlighting its therapeutic potential for degenerative spinal disorders. These findings support further clinical exploration of RTA 408 as a novel Nrf2-targeted therapy for IDD.

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Publication Details

Journal
Arthritis Research & Therapy
Published
2025-06-19
DOI
https://doi.org/10.1186/s13075-025-03588-7
Citations
3
Primary Topic
Spine and Intervertebral Disc Pathology
Type
article
Field-Weighted Citation Impact
4.41

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article

RTA 408 attenuates TBHP-Induced apoptosis in nucleus pulposus cells via Nrf2/ARE and NF-κB signaling pathways: in vitro and in vivo evidence for mitigating rats’ intervertebral disc degeneration

Zengxin Jiang, Jichang Fei, Li‐Han Chen, Mengxuan Bian et al.
3 citations
Arthritis Research & Therapy
Spine and Intervertebral Disc Pathology
4.41
article

RTA 408 attenuates TBHP-Induced apoptosis in nucleus pulposus cells via Nrf2/ARE and NF-κB signaling pathways: in vitro and in vivo evidence for mitigating rats’ intervertebral disc degeneration

Zengxin Jiang, Jichang Fei, Li‐Han Chen, Mengxuan Bian, Defang Li, Weibin Chen, Qingmin Zeng, Jingping Wu
article en
3 citations

Abstract

RTA 408 mitigates oxidative stress-induced NPC apoptosis and ECM degradation via dual modulation of Nrf2/ARE activation and NF-κB suppression. Systemic administration of RTA 408 delays IDD progression in vivo, highlighting its therapeutic potential for degenerative spinal disorders. These findings support further clinical exploration of RTA 408 as a novel Nrf2-targeted therapy for IDD.

Arthritis Research & TherapyVol. 27(1)
Fujian Medical University (CN), Fudan University (CN), Jinshan Hospital of Fudan University (CN), First Affiliated Hospital of Fujian Medical University (CN), Zhongshan Hospital (CN)
National Natural Science Foundation of China
Zero hunger
Openalex Percentile: Top 6%
Spine and Intervertebral Disc Pathology
4.41
DOIOpen Access PDFOpenAlex
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RTA 408 attenuates TBHP-Induced apoptosis in nucleus pulposus cells via Nrf2/ARE and NF-κB signaling pathways: in vitro and in vivo evidence for mitigating rats’ intervertebral disc degeneration — Zengxin Jiang, Jichang Fei, et al. · Arthritis Research & Therapy (2025) | TGRS Research Map | TGRS