The HIF-1α signaling pathway: A key approach to revealing the effects of Scutellaria baicalensis Georgi against lipopolysaccharide-induced spontaneous abortion
This study established a rigorous framework for screening and analyzing the therapeutic components of SBG and revealed that SBG is specifically effective against ESAs and maternal-fetal interface inflammation through the HIF-1α signaling pathway. These findings highlight SBG as a therapeutic agent for ESA and provide a foundation for future mechanistic studies.
Authors
- Zeyi Guo
- Weijun Ding (ORCID: https://orcid.org/0000-0002-0419-0900)
- Huan Wang (ORCID: https://orcid.org/0000-0001-8530-7367)
- Jinzhu Huang (ORCID: https://orcid.org/0000-0001-5079-744X)
- Jingjing Gao (ORCID: https://orcid.org/0000-0002-8521-2541)
- Ming Yue (ORCID: https://orcid.org/0000-0002-1700-7052)
- Linwen Deng (ORCID: https://orcid.org/0000-0002-4100-8581)
- Hang Zhou (ORCID: https://orcid.org/0009-0009-3784-8025)
Institutions
- Chengdu Medical College (CN)
- Chengdu University (CN)
- Sichuan Academy of Traditional Chinese Medicine (CN)
- Second Affiliated Hospital of Chengdu University of Traditional Chinese (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1016/j.phymed.2025.157013
- Primary Topic
- Flavonoids in Medical Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Innovative Research Group Project of the National Natural Science Foundation of China
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Department of Science and Technology of Sichuan Province
- Chengdu University of Traditional Chinese Medicine
- Sichuan Provincial Administration of Traditional Chinese Medicine
- Natural Science Foundation of Sichuan Province
- Postdoctoral Research Foundation of China
- Key Research and Development Program of Sichuan Province