Error evaluation and stability analysis of numerical schemes in multiple sclerosis modeling

This study presents a mathematical model for Multiple Sclerosis (MS) analyzed using the finite difference method and the fourth-order Runge-Kutta (RK4) method. A comparative error analysis shows strong agreement between both methods, with the finite difference approach closely aligning with RK4, as indicated by low Mean Squared Error (MSE), Mean Absolute Error (MAE), and maximum absolute error values. While RK4 provides superior accuracy and stability for long-term simulations, the finite difference method remains a practical and computationally efficient alternative. These findings underscore the potential of mathematical modeling combined with numerical techniques to enhance the understanding of MS dynamics and support the development of optimized intervention strategies. Future research will concentrate on refining the model through the integration of additional biological parameters and clinical data to improve its predictive accuracy.

Authors

Institutions

Publication Details

Journal
Ain Shams Engineering Journal
Published
2025-06-19
DOI
https://doi.org/10.1016/j.asej.2025.103551
Primary Topic
Mathematical Biology Tumor Growth
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Error evaluation and stability analysis of numerical schemes in multiple sclerosis modeling

Zeeshan Afzal, Mansoor H. Alshehri
Ain Shams Engineering Journal
Mathematical Biology Tumor Growth
article

Error evaluation and stability analysis of numerical schemes in multiple sclerosis modeling

Zeeshan Afzal, Mansoor H. Alshehri
article en

Abstract

This study presents a mathematical model for Multiple Sclerosis (MS) analyzed using the finite difference method and the fourth-order Runge-Kutta (RK4) method. A comparative error analysis shows strong agreement between both methods, with the finite difference approach closely aligning with RK4, as indicated by low Mean Squared Error (MSE), Mean Absolute Error (MAE), and maximum absolute error values. While RK4 provides superior accuracy and stability for long-term simulations, the finite difference method remains a practical and computationally efficient alternative. These findings underscore the potential of mathematical modeling combined with numerical techniques to enhance the understanding of MS dynamics and support the development of optimized intervention strategies. Future research will concentrate on refining the model through the integration of additional biological parameters and clinical data to improve its predictive accuracy.

Ain Shams Engineering JournalVol. 16(10)
King Saud University (SA), Lahore Garrison University (PK), King Salman Center for Disability Research (SA)
King Salman Center for Disability Research
Openalex Percentile: Top 84%
Mathematical Biology Tumor Growth
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.