Heterogeneous effects of sodium–glucose cotransporter‐2 inhibitors compared to dipeptidyl peptidase‐4 inhibitors on nephrolithiasis in older adults with type 2 diabetes
In older adults with T2D, SGLT2i use was associated with a lower risk of nephrolithiasis compared to DPP4i, particularly among men, NHB individuals, and those without baseline nephrolithiasis. Although causality cannot be established, these findings provide real-world evidence supporting a potential benefit of SGLT2is in reducing nephrolithiasis risk, offering valuable insights to guide the selection of glucose-lowering drugs in older adults with T2D.
Authors
- Rotana M. Radwan (ORCID: https://orcid.org/0000-0003-0061-0637)
- Jiang Bian (ORCID: https://orcid.org/0000-0002-2238-5429)
- Vivian Fonseca (ORCID: https://orcid.org/0000-0002-3381-7151)
- Yu Huang (ORCID: https://orcid.org/0000-0001-7373-4716)
- Desmond Schatz (ORCID: https://orcid.org/0000-0002-1044-5762)
- Yujia Li (ORCID: https://orcid.org/0000-0002-5655-5254)
- Yi Guo (ORCID: https://orcid.org/0000-0003-0587-4105)
- Jingchuan Guo (ORCID: https://orcid.org/0000-0001-9799-2592)
- Lizheng Shi (ORCID: https://orcid.org/0000-0002-7827-6766)
- Wenxi Huang (ORCID: https://orcid.org/0000-0002-8237-6401)
- Hui Shao (ORCID: https://orcid.org/0000-0002-4088-546X)
- Yongkang Zhang (ORCID: https://orcid.org/0000-0001-6312-9686)
Institutions
- Tulane University (US)
- Indiana University Health (US)
- Regenstrief Institute (US)
- Emory University (US)
- Cornell University (US)
- University of Florida (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Florida College (US)
Publication Details
- Journal
- Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1002/phar.70030
- Primary Topic
- Potassium and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of Diabetes and Digestive and Kidney Diseases