<scp>AdipoRon</scp> attenuates steatosis, inflammation and fibrosis in murine diet‐induced <scp>NASH</scp> via inhibiting <scp>ER</scp> stress
Our findings establish AdipoRon as a potent inhibitor of ER stress, effectively counteracting metabolic stress-induced NASH pathogenesis. These results highlight its translational promise as a targeted therapy for NASH, addressing critical unmet clinical needs.
Authors
- Yongmei Xie (ORCID: https://orcid.org/0000-0002-7913-0283)
- Chuanyue Gao
- Lulin Nie
- Bocheng Xiong
- Shangming Li (ORCID: https://orcid.org/0009-0001-9243-9832)
- Haihui Xie (ORCID: https://orcid.org/0000-0001-7406-8268)
- Kaiwu He (ORCID: https://orcid.org/0000-0002-8131-5850)
- Wei Wu (ORCID: https://orcid.org/0000-0002-0858-8086)
- Huan Zhang (ORCID: https://orcid.org/0000-0002-6051-6186)
Institutions
- Guangdong Medical College (CN)
- Sichuan University (CN)
- Key Laboratory of Guangdong Province (CN)
- Shenzhen Center for Disease Control and Prevention (CN)
- Dongguan People’s Hospital (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1111/dom.16542
- Citations
- 3
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Sanming Project of Medicine in Shenzhen