Novel findings regarding the role of the endocannabinoid system in pediatric functional gastrointestinal disorders
Children with FGID exhibit significant pain in nongastrointestinal regions. The higher concentrations of PEA found in the FGID subjects, also occurring in other chronic pain conditions, could reflect a compensatory response due to feedback loops from a downregulated or nonresponsive PPAR system, while the absence of the expected relationship between pain intensity and PEA levels in the FGID group suggests that the PPAR system may not be functioning normally.
Authors
- Gisela G. Chelimsky (ORCID: https://orcid.org/0000-0001-5318-0103)
- Cecilia J. Hillard (ORCID: https://orcid.org/0000-0002-9678-748X)
- Lisa L. Conant (ORCID: https://orcid.org/0000-0002-5050-3437)
- Serge Marchand (ORCID: https://orcid.org/0000-0002-4234-5977)
- Thomas C. Chelimsky (ORCID: https://orcid.org/0000-0002-3232-5710)
- Liyun Zhang (ORCID: https://orcid.org/0000-0001-5882-2179)
- Pippa Margaret Simpson (ORCID: https://orcid.org/0000-0003-1458-3748)
Institutions
- Université de Sherbrooke (CA)
- Virginia Commonwealth University (US)
- Medical College of Wisconsin (US)
Publication Details
- Journal
- PAIN Reports
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1097/pr9.0000000000001273
- Citations
- 1
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Medical College of Wisconsin