A longitudinal study of the 5xFAD mouse retina delineates Amyloid beta (Aβ)-mediated retinal pathology from age-related changes
Chronic Aβ exposure led to the earlier development of retinopathy-linked features, the identification of which advances our understanding of how Aβ contributes to multifaceted retinopathies. These were distinguishable from wider age-related changes and non-specific influences of retinal degeneration alleles in 5xFAD mice. Longitudinal analyses revealed sex and age-related limitations and important 3Rs considerations for future studies using 5xFAD mice.
Authors
- David S. Chatelet (ORCID: https://orcid.org/0000-0002-1856-3982)
- Jenny Scott (ORCID: https://orcid.org/0000-0002-4920-0914)
- Eloise Keeling (ORCID: https://orcid.org/0000-0003-0399-359X)
- Aída Sánchez‐Bretaño (ORCID: https://orcid.org/0000-0002-0156-6781)
- Tutte Newall
- J. Arjuna Ratnayaka (ORCID: https://orcid.org/0000-0002-1027-6938)
- Neil Smyth (ORCID: https://orcid.org/0000-0002-3734-2149)
- Jay Self (ORCID: https://orcid.org/0000-0002-1030-9963)
- Andrew Lotery (ORCID: https://orcid.org/0000-0001-5541-4305)
- Sudha Priya Soundara Pandi (ORCID: https://orcid.org/0000-0002-0308-0742)
- Savannah A. Lynn (ORCID: https://orcid.org/0000-0003-2513-3144)
- Helena Lee (ORCID: https://orcid.org/0000-0002-2573-9536)
- Larry Parker
- A. C. Muir (ORCID: https://orcid.org/0000-0002-7409-384X)
Institutions
- Southampton General Hospital (GB)
- University Hospital Southampton NHS Foundation Trust (GB)
- University of Southampton (GB)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1186/s13195-025-01784-w
- Citations
- 3
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Sight Research UK
- National Centre for the Replacement, Refinement and Reduction of Animals in Research