CHANGES IN RABBITS’ BLOOD INDICATORS WHEN USING POTASSIUM HUMATE 80 AS A RADIOPROTECTOR

The aim of the study is to evaluate the radioprotective properties of the drug Potassium Humate 80 under tritium exposure in subclinical doses on the body of rabbits. Objectives: to determine changes in hematological and biochemical parameters and phagocytic activity of blood cells in rabbits under the influence of tritium water and when using the radioprotector Potassium Humate 80. The study was conducted at the Department of the Institute of Biology and Microbiology, in the Research and Testing Center of the Federal State Budgetary Educational Institution of Higher Education Krasnoyarsk State Agrarian University. The paper presents data on tritium pollution of the biosphere, and determines its migration activity in environmental components. The mechanisms of tritium absorption and migration in the body of animals, its impact on health and productivity are described. The article provides a classification of radioprotectors, their characteristics, mechanisms of action, and recommended doses of radioprotective drugs. The degree of change in phagocytic activity, hematological and biochemical indices of venous blood of rabbits under the influence of tritium water (62.29 mGy) and under the application of radioprotector Potassium Humate 80 was determined. Radioprotective properties of the drug Potassium Humate 80 under tritium influence in subclinical doses on the organism of rabbits were estimated. At the dose load of 62.29 mGy of tritium influence in the bloodstream of rabbits erythrocytosis, leukocytosis and increase of hemoglobin level are registered, which is obliged to stimulating effect of tritium. However, at subclinical doses of tritium in the blood serum the amount of alpha-globulins, AST, alkaline phosphatase decreases and the content of beta-globulins and ALT increases, which indicates the toxic effect of tritium on the liver and kidneys. The use of the radioprotector Potassium Humate 80 on the 20th day restores the amount of formed elements of the blood, biochemical parameters of the blood of rabbits to control and reference values. The use of Potassium Humate 80 increases the phagocytic activity of blood cells to control values. With tritium exposure, the use of Potassium Humate 80 in a dose of 10–4 g/l is recommended as a radioprotector.