FEATURES OF THE BLOOD SERUM AMINO ACID COMPOSITION OF CATS WITH NON-INFECTIOUS HEPATITIS

The aim of the study is to investigate changes in the amino acid composition of the blood serum of cats with non-infectious hepatitis. The study was conducted on cats using the analogue principle, with 6 animals in each group. The diagnosis of hepatitis was based on the results of clinical and laboratory examination of cats. The first group of animals served as a control (healthy). The second group included animals before treatment (sick). The third and fourth groups of animals – after treatment. The third group was treated according to the following scheme: Essentiale (0.5 ml), vitamin B6 (1 ml), Enroxil (0.49 ml, 7 days), Heptral (1.2 ml, 7 days), Omez (0.49 ml, 7 days), Famotidine (1.2 ml, 3 days), Papaverine and Mariopital (0.49 ml, 3 days). The fourth group was additionally administered Vitaselcin TM, once, at a dose of 0.15 ml/kg of body weight. Blood for the study was taken on the 10th day. In sick animals, a reliable decrease in tryptophan, lysine, valine, aspartic acid, glutamic acid and ornithine was found, but an increase in methionine and phenylalanine occurred. After treatment, the amino acid content in the blood serum returned to the level of healthy animals (control). In animals of the fourth group, there was a reliable increase in amino acids: valine – by 19.0 %; tryptophan – by 14.8; aspartic acid – by 18.6; alanine – by 12.4; ornithine – by 18.4 % relative to the initial level (the second group of animals). Phenylalanine, methionine, glutamic acid, tyrosine, glutamine returned to the level of amino acids in the blood serum of control animals. Fisher's coefficient in control animals was within the normal range (2.16). In animals of the second group, the lowest value was established – 1.46, which indicates liver damage. After treatment, in animals of the third and fourth groups, the desired indicator returned to the level of healthy animals.